Functional consequences of locus coeruleus degeneration in Alzheimer's disease.

  title={Functional consequences of locus coeruleus degeneration in Alzheimer's disease.},
  author={David Weinshenker},
  journal={Current Alzheimer research},
  volume={5 3},
Alzheimer's disease (AD) is the most common cause of cognitive impairment in older patients, and its prevalence is expected to soar in coming decades. Neuropathologically, AD is characterized by beta-amyloid-containing plaques, tau-containing neurofibrillary tangles, and cholinergic neuronal loss. In addition to the hallmark of memory loss, the disease is associated with other neuropsychiatric and behavioral abnormalities, including psychosis, aggression, and depression. Although cholinergic… CONTINUE READING
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