Functional consequences of binding macrolides to ribosomes.

@article{Menninger1985FunctionalCO,
  title={Functional consequences of binding macrolides to ribosomes.},
  author={John R. Menninger},
  journal={The Journal of antimicrobial chemotherapy},
  year={1985},
  volume={16 Suppl A},
  pages={23-34}
}
Macrolide antibiotics bind to the large subunit of procaryotic ribosomes and perturb protein synthesis. There are two competing models to explain this perturbation: (1) shortly after initiation of the polypeptide chain, peptide bond formation and/or translocation is inhibited by the presence of macrolides that are bound in the ribosome 'tunnel' through which the nascent peptide travels; (2) bound macrolides loosen the interaction between the ribosome and peptidyl-tRNA, which therefore… CONTINUE READING

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