Functional consequences of altering myocardial adrenergic receptor signaling.

@article{Koch2000FunctionalCO,
  title={Functional consequences of altering myocardial adrenergic receptor signaling.},
  author={Walter J. Koch and Robert J Lefkowitz and Howard A Rockman},
  journal={Annual review of physiology},
  year={2000},
  volume={62},
  pages={
          237-60
        }
}
From the ability to successfully manipulate the mouse genome has come important transgenic and gene-targeted knockout models that impact many areas of biomedical research. Genetically engineered mouse models geared toward the study of cardiovascular regulation have recently been described and provide powerful tools to study normal and compromised cardiac physiology. The genetic manipulation of the adrenergic receptor (AR) signaling system in the heart, including its regulation by desensitizing… CONTINUE READING

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