Functional consequences of acute cocaine treatment depend on route of administration

@article{Porrino1993FunctionalCO,
  title={Functional consequences of acute cocaine treatment depend on route of administration},
  author={Linda J. Porrino},
  journal={Psychopharmacology},
  year={1993},
  volume={112},
  pages={343-351}
}
The 2-[14C]deoxyglucose method was used to compare the effects of the acute administration of cocaine by two different routes, intravenous and intraperitoneal, on rates of local cerebral glucose utilization in freely moving rats. Doses were initially chosen on the basis of their ability to elicit equivalent increases in locomotor activity during the experimental procedure, and the time of cocaine administration relative to 2-[14C]deoxyglucose infusion was chosen so that the maximal behavioral… CONTINUE READING
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