Functional consequences of S1P receptor modulation in rat oligodendroglial lineage cells.

@article{Jung2007FunctionalCO,
  title={Functional consequences of S1P receptor modulation in rat oligodendroglial lineage cells.},
  author={Cha Gyun Jung and Hye Jung Kim and Veronique E Miron and Stuart Cook and Timothy E Kennedy and Carolyn A. Foster and Jack P. Antel and Betty Soliven},
  journal={Glia},
  year={2007},
  volume={55 16},
  pages={1656-67}
}
Fingolimod (FTY720) and its phosphorylated form FTY720P are modulators of sphingosine-1-phosphate (S1P) receptors, which are G-protein coupled receptors linked to cell migration and vascular maturation. The efficacy of FTY720 in autoimmune diseases such as multiple sclerosis and its animal models has been attributed to its inhibition of lymphocyte trafficking to target organs. In this study, we examined the role of S1P receptors in cultured rat oligodendrocytes (OLGs) and OLG progenitor cells… CONTINUE READING

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