Functional connectivity alternation of the thalamus in restless legs syndrome patients during the asymptomatic period: a resting-state connectivity study using functional magnetic resonance imaging.

@article{Ku2014FunctionalCA,
  title={Functional connectivity alternation of the thalamus in restless legs syndrome patients during the asymptomatic period: a resting-state connectivity study using functional magnetic resonance imaging.},
  author={Jeonghun Ku and Yong Won Cho and Yeong Seon Lee and Hye-Jin Moon and Hyukwon Chang and Christopher J. Earley and Richard P. Allen},
  journal={Sleep medicine},
  year={2014},
  volume={15 3},
  pages={289-94}
}
BACKGROUND Restless legs syndrome (RLS) is a primary sensory disorder with a secondary motor component (e.g., urge to move), and the thalamus is known to play a central role in RLS. The purpose of our study was to explore the intrinsic changes in the thalamocortical circuit in RLS patients using a resting-state functional magnetic resonance imaging (fMRI) paradigm. METHODS Resting-state fMRIs were obtained in the morning from 25 idiopathic RLS patients who were not using RLS medications and… CONTINUE READING