Functional complexity of the Leishmania granuloma and the potential of in silico modeling

@inproceedings{Moore2013FunctionalCO,
  title={Functional complexity of the Leishmania granuloma and the potential of in silico modeling},
  author={John W. J. Moore and Daniel Moyo and Lynette Beattie and Paul S. Andrews and Jonathan Timmis and Paul M. Kaye},
  booktitle={Front. Immun.},
  year={2013}
}
In human and canine visceral leishmaniasis and in various experimental models of this disease, host resistance is strongly linked to efficient granuloma development. However, it is unknown exactly how the granuloma microenvironment executes an effective antileishmanial response. Recent studies, including using advanced imaging techniques, have improved our understanding of granuloma biology at the cellular level, highlighting heterogeneity in granuloma development and function, and hinting at… CONTINUE READING
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