Functional complementation of truncated human skeletal-muscle chloride channel (hClC-1) using carboxyl tail fragments.

@article{Wu2006FunctionalCO,
  title={Functional complementation of truncated human skeletal-muscle chloride channel (hClC-1) using carboxyl tail fragments.},
  author={Weiping Wu and G Y Rychkov and Bernard P Hughes and Allan H Bretag},
  journal={The Biochemical journal},
  year={2006},
  volume={395 1},
  pages={89-97}
}
Crystal structures of bacterial CLC (voltage-gated chloride channel family) proteins suggest the arrangement of permeation pores and possible gates in the transmembrane region of eukaryotic CLC channels. For the extensive cytoplasmic tails of eukaryotic CLC family members, however, there are no equivalent structural predictions. Truncations of cytoplasmic tails in different places or point mutations result in loss of function or altered gating of several members of the CLC family, suggesting… CONTINUE READING

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