Functional competence of T cells in the absence of glycosylphosphatidylinositol-anchored proteins caused by T cell-specific disruption of the Pig-a gene.

@article{Takahama1998FunctionalCO,
  title={Functional competence of T cells in the absence of glycosylphosphatidylinositol-anchored proteins caused by T cell-specific disruption of the Pig-a gene.},
  author={Yousuke Takahama and Kohshi Ohishi and Yuko Tokoro and Takehiko Sugawara and Yoshitaka Yoshimura and Masaru Okabe and Tomohiro Kinoshita and J. Takahashi Takeda},
  journal={European journal of immunology},
  year={1998},
  volume={28 7},
  pages={2159-66}
}
T lymphocytes express various glycosylphosphatidylinositol (GPI)-anchored surface proteins, such as Thy-1 and Ly-6A. However, functional contribution of GPI-anchored proteins in T cell activation is as yet poorly understood. Here we report the generation of mutant mice deficient in the expression of GPI-anchored molecules exclusively in their T cells. We established mice carrying three identically oriented lox-P sites within the Pig-a gene, which encodes a component essential for the initial… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
45 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 45 extracted citations

Similar Papers

Loading similar papers…