Functional compensation of motor function in pre-symptomatic Huntington's disease

@article{Klppel2009FunctionalCO,
  title={Functional compensation of motor function in pre-symptomatic Huntington's disease},
  author={Stefan Kl{\"o}ppel and Bogdan Draganski and Hartwig R. Siebner and Sarah J Tabrizi and Cornelius Weiller and Richard S. Frackowiak},
  journal={Brain},
  year={2009},
  volume={132},
  pages={1624 - 1632}
}
Involuntary choreiform movements are a clinical hallmark of Huntington's disease. Studies in clinically affected patients suggest a shift of motor activations to parietal cortices in response to progressive neurodegeneration. Here, we studied pre-symptomatic gene carriers to examine the compensatory mechanisms that underlie the phenomenon of retained motor function in the presence of degenerative change. Fifteen pre-symptomatic gene carriers and 12 matched controls performed button presses… CONTINUE READING

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