Functional comparison of the two gene products of Thogoto virus segment 6.

@article{Hagmaier2004FunctionalCO,
  title={Functional comparison of the two gene products of Thogoto virus segment 6.},
  author={Kathrin Hagmaier and Hans Gelderblom and Georg Kochs},
  journal={The Journal of general virology},
  year={2004},
  volume={85 Pt 12},
  pages={
          3699-708
        }
}
The sixth genomic segment of Thogoto virus (THOV) encodes two proteins, the viral matrix protein (M) and an accessory protein with an interferon (IFN)-antagonistic function named ML. M and ML are shown in this study to be structural components of the virion. Using an in vivo system based on the reconstitution of functional THOV ribonucleoprotein complexes from cloned cDNAs, it was demonstrated that M has an inhibitory effect on the viral RNA-dependent RNA polymerase (RdRP) and is essential for… Expand
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