Functional comparison of the Rev trans-activators encoded by different primate immunodeficiency virus species.

@article{Malim1989FunctionalCO,
  title={Functional comparison of the Rev trans-activators encoded by different primate immunodeficiency virus species.},
  author={Michael H Malim and S B{\"o}hnlein and Randy Fenrick and S Y Le and Jacob V. Maizel and Bryan R Cullen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1989},
  volume={86 21},
  pages={8222-6}
}
The known primate lentiviruses can be divided into two subgroups consisting of the human immunodeficiency virus type 1 (HIV-1) isolates and the related HIV type 2 (HIV-2) and simian immunodeficiency virus (SIV) isolates. HIV-1 has been shown to encode a post-transcriptional trans-activator of viral structural gene expression, termed Rev, that is essential for viral replication in culture. Here, we demonstrate that HIV-2 and SIVmac also encode functional Rev proteins. As in the case of HIV-1… CONTINUE READING

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