Functional comparison of engineered T cells carrying a native TCR versus TCR-like antibody-based chimeric antigen receptors indicates affinity/avidity thresholds.

@article{Oren2014FunctionalCO,
  title={Functional comparison of engineered T cells carrying a native TCR versus TCR-like antibody-based chimeric antigen receptors indicates affinity/avidity thresholds.},
  author={Ravit Oren and Moran Hod-Marco and Maya Haus-Cohen and Sharyn Thomas and Dan Blat and Nerri Duvshani and Galit Denkberg and Yael Elbaz and Fabrice Benchetrit and Zelig Eshhar and Hans J Stauss and Yoram Reiter},
  journal={Journal of immunology},
  year={2014},
  volume={193 11},
  pages={
          5733-43
        }
}
Adoptive transfer of Ag-specific T lymphocytes is an attractive form of immunotherapy for cancers. However, acquiring sufficient numbers of host-derived tumor-specific T lymphocytes by selection and expansion is challenging, as these cells may be rare or anergic. Using engineered T cells can overcome this difficulty. Such engineered cells can be generated using a chimeric Ag receptor based on common formats composed from Ag-recognition elements such as αβ-TCR genes with the desired specificity… CONTINUE READING
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