Functional comparison between YCF1 and MRP1 expressed in Sf21 insect cells.

@article{Ren2000FunctionalCB,
  title={Functional comparison between YCF1 and MRP1 expressed in Sf21 insect cells.},
  author={X Q Ren and Tatsuhiko Furukawa and Z S Chen and Hiroshi Okumura and Shunji Aoki and Tomoyuki Sumizawa and Ayako Tani and Masaharu Komatsu and Xingguo Mei and Shin-ichi Akiyama},
  journal={Biochemical and biophysical research communications},
  year={2000},
  volume={270 2},
  pages={608-15}
}
YCF1 is a yeast vacuole membrane transporter involved in resistance to Cd(2+) and to exogenous glutathione S-conjugate precursors. MRP1 contributes to multidrug resistance (MDR) in tumor cells. MRP1 and YCF1 have extensive amino acid sequence homology (63% amino acid similarity). We expressed MRP1 or YCF1 in insect cell membranes and compared their functions to know more about their structure-function relationships. YCF1 and MRP1 with His epitopes were expressed in Sf21 insect cells; both of… CONTINUE READING
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