Functional communication between PKC-targeted cardiac troponin I phosphorylation sites.

Abstract

Increased protein kinase C (PKC) activity is associated with heart failure, and can target multiple cardiac troponin I (cTnI) residues in myocytes, including S23/24, S43/45 and T144. In earlier studies, cTnI-S43D and/or -S45D augmented S23/24 and T144 phosphorylation, which suggested there is communication between clusters. This communication is now… (More)
DOI: 10.1016/j.abb.2017.05.019

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