Functional coevolutionary networks of the Hsp70-Hop-Hsp90 system revealed through computational analyses.

@article{Travers2007FunctionalCN,
  title={Functional coevolutionary networks of the Hsp70-Hop-Hsp90 system revealed through computational analyses.},
  author={Simon A. A. Travers and Mario A. Fares},
  journal={Molecular biology and evolution},
  year={2007},
  volume={24 4},
  pages={1032-44}
}
Currently, the identification of groups of amino acid residues that are important in the function, structure, or interaction of a protein can be both costly and prohibitively complex, involving vast numbers of mutagenesis experiments. Here, we present the application of a novel computational method, which identifies the presence of coevolution in a data set, thereby enabling the a priori identification of amino acid residues that play an important role in protein function. We have applied this… CONTINUE READING

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Effect of mutation of the TPR and DP2 domains of Sti1 on Hsp90 signaling and interaction in Saccharomyces cerevisiae

  • G. Flom, J. Weekes, J. J. Williams, J. L. Johnson.
  • Genetics.
  • 2005
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