Functional co-primary measures for clinical trials in schizophrenia: results from the MATRICS Psychometric and Standardization Study.

@article{Green2008FunctionalCM,
  title={Functional co-primary measures for clinical trials in schizophrenia: results from the MATRICS Psychometric and Standardization Study.},
  author={Michael F. Green and Keith H. Nuechterlein and R. Santiago Kern and Lyle E Baade and Wayne S. Fenton and James M. Gold and Richard S. E. Keefe and Raquelle I. Mesholam-Gately and Larry J. Seidman and Ellen Stover and Stephen R Marder},
  journal={The American journal of psychiatry},
  year={2008},
  volume={165 2},
  pages={221-8}
}
OBJECTIVE During the consensus meetings of the National Institute of Mental Health Measurement and Treatment Research to Improve Cognition in Schizophrenia (NIMH-MATRICS) Initiative, the U.S. Food and Drug Administration took the position that a drug for this purpose should show changes on 1) an accepted consensus cognitive performance measure and 2) an additional measure (i.e., a co-primary) that is considered functionally meaningful. The goal of the current study was to describe steps to… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 90 extracted citations

Merging categorical and dimensional diagnoses of mental disorders.

Epidemiology and psychiatric sciences • 2012
View 3 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 20 references

Similar Papers

Loading similar papers…