Functional cleavage of the common cytokine receptor g chain ( g c ) by calpain

Abstract

The small subunit of calpain, a calciumdependent cysteine protease, was found to interact with the cytoplasmic domain of the common cytokine receptor g chain (gc) in a yeast two-hybrid interaction trap assay. This interaction was functional as demonstrated by the ability of calpain to cleave in vitro-translated wild-type gc, but not gc containing a mutation… (More)

8 Figures and Tables

Topics

  • Presentations referencing similar topics