Functional classification of interferon-stimulated genes identified using microarrays.

  title={Functional classification of interferon-stimulated genes identified using microarrays.},
  author={Michael J. de Veer and Michelle Holko and Matt Frevel and Edward Walker and Sandy D. Der and Jayashree M. Paranjape and Robert H. Silverman and Bryan R. G. Williams},
  journal={Journal of leukocyte biology},
  volume={69 6},
Interferons (IFNs) are a family of multifunctional cytokines that activate transcription of subsets of genes. The gene products induced by IFNs are responsible for IFN antiviral, antiproliferative, and immunomodulatory properties. To obtain a more comprehensive list and a better understanding of the genes regulated by IFNs, we compiled data from many experiments, using two different microarray formats. The combined data sets identified >300 IFN-stimulated genes (ISGs). To provide new insight… CONTINUE READING
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