Functional characterizations of the androgen receptor confirm that the molecular basis of androgen action is transcriptional regulation.

@article{Rundlett1990FunctionalCO,
  title={Functional characterizations of the androgen receptor confirm that the molecular basis of androgen action is transcriptional regulation.},
  author={Stephen E. Rundlett and Xiao Ping Wu and Roger L. Miesfeld},
  journal={Molecular endocrinology},
  year={1990},
  volume={4 5},
  pages={
          708-14
        }
}
  • Stephen E. Rundlett, Xiao Ping Wu, Roger L. Miesfeld
  • Published in Molecular endocrinology 1990
  • Biology, Medicine
  • In an effort to understand the molecular basis of androgen action in the prostate, we isolated androgen receptor (AR) cDNA from rat ventral prostate cells and analyzed the transcriptional regulatory activity of the encoded protein in a cotransfection assay. We found that AR is capable of inducing chloramphenicol acetyltransferase activity more than 20-fold using the mouse mammary tumor virus LTR as a source of androgen response elements. This induction was observed in both monkey CV1 cells and… CONTINUE READING

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