Functional characterization of two splice variants of rat bad and their interaction with Bcl-w in sympathetic neurons.

@article{Hamner2001FunctionalCO,
  title={Functional characterization of two splice variants of rat bad and their interaction with Bcl-w in sympathetic neurons.},
  author={Steve Hamner and Urmas Arum{\"a}e and Y Li-Ying and Y F Sun and Mart Saarma and Dan Lindholm},
  journal={Molecular and cellular neurosciences},
  year={2001},
  volume={17 1},
  pages={97-106}
}
Neuronal cell death is in many cases regulated by competitive interactions between pro- and antiapoptotic proteins of the Bcl-2 family. In this study we have identified two splice variants of the rat proapoptotic molecule Bad, which differ in their carboxy-terminal regions. Both splice variants of Bad interacted with the antiapoptotic molecule Bcl-w as shown by yeast two-hybrid assay and by co-immunoprecipitation experiments from transfected cells. mRNA expression for the two variants of bad… CONTINUE READING
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