Functional characterization of transcription regulators that interact with the electrophile response element.

@article{Zhu2001FunctionalCO,
  title={Functional characterization of transcription regulators that interact with the electrophile response element.},
  author={Marie M Zhu and William E Fahl},
  journal={Biochemical and biophysical research communications},
  year={2001},
  volume={289 1},
  pages={212-9}
}
The electrophile response element (EpRE), also referred to as the antioxidant responsive element (ARE), is found in the 5'-regulatory region of a number of genes encoding phase II, drug-metabolizing enzymes. Gene knockout studies have demonstrated the primary regulatory role that an Nrf2:Maf dimer plays by binding to nucleotides within the EpRE consensus sequence. Current models of transcription regulation have also shown the involvement of higher-order transcriptional coactivators, proteins… CONTINUE READING
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