Functional characterization of three G protein-coupled receptors for pigment dispersing factors in Caenorhabditis elegans.

@article{Janssen2008FunctionalCO,
  title={Functional characterization of three G protein-coupled receptors for pigment dispersing factors in Caenorhabditis elegans.},
  author={Tom Janssen and Steven J. Husson and Marleen Lindemans and Inge Mertens and Suzanne Rademakers and Kris Ver Donck and Johan Geysen and Gert Jansen and Liliane Schoofs},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 22},
  pages={15241-9}
}
Here, we report the identification, cloning, and functional characterization of three Caenorhabditis elegans G protein-coupled pigment dispersing factor (PDF) receptors, which we designated as Ce_PDFR-1a, -b, and -c. They represent three splice isoforms of the same gene (C13B9.4), which share a high degree of similarity with the Drosophila PDF receptor and are distantly related to the mammalian vasoactive intestinal peptide receptors (VPAC2) and calcitonin receptors. In a reverse… CONTINUE READING

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