Functional characterization of the trans-membrane domain interactions of the Sec61 protein translocation complex beta-subunit

@article{Zhao2009FunctionalCO,
  title={Functional characterization of the trans-membrane domain interactions of the Sec61 protein translocation complex beta-subunit},
  author={Xueqiang Zhao and Jussi J{\"a}ntti},
  journal={BMC Cell Biology},
  year={2009},
  volume={10},
  pages={76 - 76}
}
In eukaryotic cells co- and post-translational protein translocation is mediated by the trimeric Sec61 complex. Currently, the role of the Sec61 complex β-subunit in protein translocation is poorly understood. We have shown previously that in Saccharomyces cerevisiae the trans-membrane domain alone is sufficient for the function of the β-subunit Sbh1p in co-translational protein translocation. In addition, Sbh1p co-purifies not only with the protein translocation channel subunits Sec61p and… CONTINUE READING

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