Functional characterization of the adenosine receptor contributing to glycogenolysis and gluconeogenesis in rat hepatocytes.

@article{Yasuda2003FunctionalCO,
  title={Functional characterization of the adenosine receptor contributing to glycogenolysis and gluconeogenesis in rat hepatocytes.},
  author={Nobuyuki Yasuda and Takashi Inoue and Tatsuo Horizoe and Kaya Nagata and Hiroe Minami and Tsutomu Kawata and Yorihisa Hoshino and Hitoshi Harada and Seiji Yoshikawa and Osamu Asano and Junsaku Nagaoka and Manabu Murakami and Shinya Abe and Seiichi Kobayashi and Isao Tanaka},
  journal={European journal of pharmacology},
  year={2003},
  volume={459 2-3},
  pages={159-66}
}
The adenosine receptor subtype mediating glucose production by glycogenolysis and gluconeogenesis was studied in primary cultured rat hepatocytes. Adenosine and adenosine agonists caused cyclic AMP accumulation in rat hepatocytes. The order of potency was 5'-N-ethylcarboxamidoadenosine (NECA)>R(-)-N(6)-(2-phenylisopropyl)adenosine (RPIA)>adenosine>2-[p-(carboxyethyl)phenylethylamino]-5'-N-ethylcarboxamidoadenosine (CGS21680). Furthermore, adenosine agonists stimulated glycogenolysis and… CONTINUE READING
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