Functional characterization of the Plasmodium falciparum and P. berghei homologues of macrophage migration inhibitory factor.

@article{Augustijn2007FunctionalCO,
  title={Functional characterization of the Plasmodium falciparum and P. berghei homologues of macrophage migration inhibitory factor.},
  author={Kevin D. Augustijn and Robert Kleemann and Joanne Thompson and Teake Kooistra and Carina E Crawford and Sarah E. Reece and Arnab Pain and Arjan H G Siebum and Chris J Janse and Andrew P Waters},
  journal={Infection and immunity},
  year={2007},
  volume={75 3},
  pages={1116-28}
}
Macrophage migration inhibitory factor (MIF) is a mammalian cytokine that participates in innate and adaptive immune responses. Homologues of mammalian MIF have been discovered in parasite species infecting mammalian hosts (nematodes and malaria parasites), which suggests that the parasites express MIF to modulate the host immune response upon infection. Here we report the first biochemical and genetic characterization of a Plasmodium MIF (PMIF). Like human MIF, histidine-tagged purified… CONTINUE READING