Functional characterization of the MKC1 gene of Candida albicans, which encodes a mitogen-activated protein kinase homolog related to cell integrity.

@article{NavarroGarca1995FunctionalCO,
  title={Functional characterization of the MKC1 gene of Candida albicans, which encodes a mitogen-activated protein kinase homolog related to cell integrity.},
  author={Federico Navarro-Garc{\'i}a and Massimo Sanchez and Jesus Pla and C{\'e}sar Nombela},
  journal={Molecular and cellular biology},
  year={1995},
  volume={15 4},
  pages={2197-206}
}
Mitogen-activated protein (MAP) kinases represent a group of serine/threonine protein kinases playing a central role in signal transduction processes in eukaryotic cells. Using a strategy based on the complementation of the thermosensitive autolytic phenotype of slt2 null mutants, we have isolated a Candida albicans homolog of Saccharomyces cerevisiae MAP kinase gene SLT2 (MPK1), which is involved in the recently outlined PKC1-controlled signalling pathway. The isolated gene, named MKC1 (MAP… CONTINUE READING

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Activity of the yeast MAP kinase homologue Slt2 is critically required for cell integrity at 378C

  • H. Martı́n, J. Arroyo, M. Sánchez, M. Molina, C. Nombela
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