Functional characterization of the Frt1 sugar transporter and of fructose uptake in Kluyveromyces lactis

@article{Diezemann2003FunctionalCO,
  title={Functional characterization of the Frt1 sugar transporter and of fructose uptake in Kluyveromyces lactis},
  author={Anja Diezemann and Eckhard Boles},
  journal={Current Genetics},
  year={2003},
  volume={43},
  pages={281-288}
}
Most yeast hexose transporters studied so far at the molecular level mediate facilitated diffusion of glucose and fructose. Here, we report that a novel Kluyveromyces lactis gene, FRT1, encodes a proton-coupled fructose-uptake transporter. Frt1, when expressed in a Saccharomyces cerevisiae hxt null mutant strain that is unable to take up monosaccharides, restored growth on fructose. Determination of substrate specificities and kinetic parameters revealed Frt1 as a fructose transporter with a K… CONTINUE READING

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