Functional characterization of the Escherichia coli Fis-DNA binding sequence.

Abstract

The Escherichia coli protein Fis is remarkable for its ability to interact specifically with DNA sites of highly variable sequences. The mechanism of this sequence-flexible DNA recognition is not well understood. In a previous study, we examined the contributions of Fis residues to high-affinity binding at different DNA sequences using alanine-scanning… (More)
DOI: 10.1016/j.jmb.2007.11.101

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