Functional characterization of the Candida albicans MNT1 mannosyltransferase expressed heterologously in Pichia pastoris.

@article{Thomson2000FunctionalCO,
  title={Functional characterization of the Candida albicans MNT1 mannosyltransferase expressed heterologously in Pichia pastoris.},
  author={Lynn M. Thomson and Steven Bates and Soh Yamazaki and Mikio Arisawa and Yuko Aoki and Neil A R Gow},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 25},
  pages={18933-8}
}
The alpha1,2-mannosyltransferase gene MNT1 of the human fungal pathogen Candida albicans has been shown to be important for its adherence to various human surfaces and for virulence (Buurman, E. T. , Westwater, C., Hube, B., Brown, A. P. J., Odds, F. C., and Gow, N. A. R. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 7670-7675). The CaMnt1p is a type II membrane protein, which is part of a family of proteins that are important for both O- and N-linked mannosylation in fungi and which represent a… CONTINUE READING

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