Functional characterization of rat submaxillary gland muscarinic receptors using microphysiometry

@article{Meloy2001FunctionalCO,
  title={Functional characterization of rat submaxillary gland muscarinic receptors using microphysiometry},
  author={T. D. Meloy and D. V. Daniels and S. Hegde and R. Eglen and A. Ford},
  journal={British Journal of Pharmacology},
  year={2001},
  volume={132}
}
Muscarinic cholinoceptors (MChR) in freshly dispersed rat salivary gland (RSG) cells were characterized using microphysiometry to measure changes in acidification rates. Several non‐selective and selective muscarinic antagonists were used to elucidate the nature of the subtypes mediating the response to carbachol. The effects of carbachol (pEC50=5.74±0.02 s.e.mean; n=53) were highly reproducible and most antagonists acted in a surmountable, reversible fashion. The following antagonist rank… Expand
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