Functional characterization of rat submaxillary gland muscarinic receptors using microphysiometry

  title={Functional characterization of rat submaxillary gland muscarinic receptors using microphysiometry},
  author={T. D. Meloy and D. V. Daniels and S. Hegde and R. Eglen and A. Ford},
  journal={British Journal of Pharmacology},
Muscarinic cholinoceptors (MChR) in freshly dispersed rat salivary gland (RSG) cells were characterized using microphysiometry to measure changes in acidification rates. Several non‐selective and selective muscarinic antagonists were used to elucidate the nature of the subtypes mediating the response to carbachol. The effects of carbachol (pEC50=5.74±0.02 s.e.mean; n=53) were highly reproducible and most antagonists acted in a surmountable, reversible fashion. The following antagonist rank… Expand
Effects of ageing on muscarinic receptor subtypes and function in rat urinary bladder
Muscarinic receptor subtypes in the alimentary tract.
  • G. Tobin, D. Giglio, O. Lundgren
  • Biology, Medicine
  • Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
  • 2009
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Differential effects of paraoxon on the M3 muscarinic receptor and its effector system in rat submaxillary gland cells.
Characterization of the functional muscarinic receptors in the rat urinary bladder
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Antagonist binding profiles of five cloned human muscarinic receptor subtypes.
Muscarinic M3 receptors are coupled to two signal transduction pathways in rat submandibular cells.
Functional responses of cloned muscarinic receptors expressed in CHO-K1 cells.
Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells.