Functional characterization of phosphorylation sites in dynamin-related protein 1.

Abstract

Dynamin-related protein 1 is member of the dynamin-family of large GTPases. Similar to the endocytosis motor dynamin, Drp1 uses GTP hydrolysis to power constriction of the outer mitochondrial membrane and ultimately mitochondrial division. Dynamin phosphorylation in its unique C-terminal proline-rich domain interferes with binding of accessory proteins that… (More)
DOI: 10.1016/S0076-6879(09)05013-7

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