Functional characterization of p53 molecules expressed in human squamous cell carcinomas of the head and neck.

@article{Yeudall1997FunctionalCO,
  title={Functional characterization of p53 molecules expressed in human squamous cell carcinomas of the head and neck.},
  author={W A Yeudall and Judit Jakus and John F. Ensley and Keith C. Robbins},
  journal={Molecular carcinogenesis},
  year={1997},
  volume={18 2},
  pages={89-96}
}
Mutation of the p53 tumor suppressor gene has been demonstrated in a large proportion of human head and neck squamous cell carcinomas (HNSCCs) and has been assumed to play a role in the pathogenesis of these tumors, although no formal evidence of functional aberration has been demonstrated. In this study, we isolated cDNA clones encoding the entire p53 coding region from six human HNSCC cell lines that showed aberrant patterns of p53 expression in the parental cells, analyzed their nucleotide… CONTINUE READING