Functional characterization of melanocortin-4 receptor mutations associated with childhood obesity.

@article{Tao2003FunctionalCO,
  title={Functional characterization of melanocortin-4 receptor mutations associated with childhood obesity.},
  author={Ya-Xiong Tao and Deborah L Segaloff},
  journal={Endocrinology},
  year={2003},
  volume={144 10},
  pages={4544-51}
}
The melanocortin-4 receptor (MC4R) is a member of the rhodopsin-like G protein-coupled receptor family. The binding of alpha-MSH to the MC4R leads to increased cAMP production. Recent pharmacological and genetic studies have provided compelling evidence that MC4R is an important regulator of food intake and energy homeostasis. Allelic variants of MC4R were reported in some children with early-onset severe obesity. However, few studies have been performed to confirm that these allelic variants… CONTINUE READING

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A novel melanocortin 4 receptor gene (MC4R) mutation associated with severe obesity

Lee Y-S, Poh LK-S, Loke K-Y
Program of the 84th Annual Meeting of The Endocrine Society, • 2002

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