Functional characterization of mammalian inositol 1,4,5-trisphosphate receptor isoforms.

@article{Tu2005FunctionalCO,
  title={Functional characterization of mammalian inositol 1,4,5-trisphosphate receptor isoforms.},
  author={Huiping Tu and Zhengnan Wang and Elena D. Nosyreva and Humbert de Smedt and Ilya B Bezprozvanny},
  journal={Biophysical journal},
  year={2005},
  volume={88 2},
  pages={1046-55}
}
Inositol 1,4,5-trisphosphate receptors (InsP3R) play a key role in intracellular calcium (Ca2+) signaling. Three mammalian InsP3R isoforms--InsP3R type 1 (InsP3R1), InsP3R type 2 (InsP3R2), and InsP3R type 3 (InsP3R3) are expressed in mammals, but the functional differences between the three mammalian InsP3R isoforms are poorly understood. Here we compared single-channel behavior of the recombinant rat InsP3R1, InsP3R2, and InsP3R3 expressed in Sf9 cells, reconstituted into planar lipid… CONTINUE READING
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