Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation.

@article{Poul2003FunctionalCO,
  title={Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation.},
  author={Emmanuel Le Poul and C{\'e}cile Loison and Sofie Struyf and Jean-Yves Springael and Vincent J Lannoy and Marie-Eve Decobecq and St{\'e}phane Br{\'e}zillon and Vincent J. Dupriez and G. Vassart and Jo Van Damme and Marc Parmentier and Michel Detheux},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 28},
  pages={
          25481-9
        }
}
Short chain fatty acids (SCFAs), including acetate, propionate, and butyrate, are produced at high concentration by bacteria in the gut and subsequently released in the bloodstream. Basal acetate concentrations in the blood (about 100 microm) can further increase to millimolar concentrations following alcohol intake. It was known previously that SCFAs can activate leukocytes, particularly neutrophils. In the present work, we have identified two previously orphan G protein-coupled receptors… CONTINUE READING

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