Functional characterization of human IgG, IgM, and IgA antibody directed to the capsule of Haemophilus influenzae type b.

@article{Schreiber1986FunctionalCO,
  title={Functional characterization of human IgG, IgM, and IgA antibody directed to the capsule of Haemophilus influenzae type b.},
  author={John R. Schreiber and V A Barrus and K Lynn Cates and George R. Siber},
  journal={The Journal of infectious diseases},
  year={1986},
  volume={153 1},
  pages={8-16}
}
Antibody to the capsular polysaccharide (CP) of Haemophilus influenzae b (Hib) is bactericidal, opsonic, and protective. Minimum protective levels of primarily IgG antibody to Hib CP, calculated from passive immunization studies, have been found to be approximately .06-.15 microgram/ml of serum. The human response to antigenic challenge with the Hib capsule, however, includes production of antibody to Hib CP of different isotypes whose function against Hib is unclear. In order to characterize… CONTINUE READING

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