Functional characterization of human Cd33+ And Cd11b+ myeloid-derived suppressor cell subsets induced from peripheral blood mononuclear cells co-cultured with a diverse set of human tumor cell lines

@inproceedings{Lechner2011FunctionalCO,
  title={Functional characterization of human Cd33+ And Cd11b+ myeloid-derived suppressor cell subsets induced from peripheral blood mononuclear cells co-cultured with a diverse set of human tumor cell lines},
  author={Melissa G. Lechner and Carolina Megiel and Sarah M. Russell and Brigid Bingham and Nicholas Arger and Tammy T. Woo and Alan L. Epstein},
  booktitle={Journal of Translational Medicine},
  year={2011}
}
Tumor immune tolerance can derive from the recruitment of suppressor cell populations, including myeloid-derived suppressor cells (MDSC). In cancer patients, MDSC accumulation correlates with increased tumor burden, but the mechanisms of MDSC induction remain poorly understood. This study examined the ability of human tumor cell lines to induce MDSC from healthy donor PBMC using in vitro co-culture methods. These human MDSC were then characterized for morphology, phenotype, gene expression, and… CONTINUE READING

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