Functional characterization of human C3/cobra venom factor hybrid proteins for therapeutic complement depletion.

@article{Fritzinger2009FunctionalCO,
  title={Functional characterization of human C3/cobra venom factor hybrid proteins for therapeutic complement depletion.},
  author={David C. Fritzinger and Brian E Hew and M. Thorne and Michael K. Pangburn and Bert J C Janssen and Piet Gros and C Vogel},
  journal={Developmental and comparative immunology},
  year={2009},
  volume={33 1},
  pages={105-16}
}
Cobra venom factor (CVF) is a structural and functional analog of complement C3 isolated from cobra venom. Both CVF and C3b can bind factor B and subsequently form the bimolecular C3/C5 convertases CVF,Bb or C3b,Bb, respectively. The two homologous enzymes exhibit several differences of which the difference in physico-chemical stability is most important, allowing continuous activation of C3 and C5 by CVF,Bb, leading to serum complement depletion. Here we describe the detailed functional… CONTINUE READING

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