Functional characterization of canine interferon-lambda.

@article{Fan2014FunctionalCO,
  title={Functional characterization of canine interferon-lambda.},
  author={Wenhui Fan and Lei Xu and Liqian Ren and Hongren Qu and Jing zhou Li and Jingjing Liang and Wenjun Liu and Limin Yang and Tingrong Luo},
  journal={Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research},
  year={2014},
  volume={34 11},
  pages={848-57}
}
In this study, we provide the first comprehensive annotation of canine interferon-λ (CaIFN-λ, type III IFN). Phylogenetic analysis based on genomic sequences indicated that CaIFN-λ is located in the same branch with Swine IFN-λ1 (SwIFN-λ), Bat IFN-λ1 (BaIFN-λ), and human IFN-λ1 (HuIFN-λ1). CaIFN-λ was cloned, expressed in Escherichia coli, and purified to further investigate the biological activity in vitro. The recombinant CaIFN-λ (rCaIFN-λ) displayed potent antiviral activity on both… CONTINUE READING
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