Functional characterization of basolateral and luminal dopamine receptors in rabbit CCD.

@article{Saito2001FunctionalCO,
  title={Functional characterization of basolateral and luminal dopamine receptors in rabbit CCD.},
  author={Osamu Saito and Yasuhiro Ando and Eiji Kusano and Yasushi Asano},
  journal={American journal of physiology. Renal physiology},
  year={2001},
  volume={281 1},
  pages={
          F114-22
        }
}
Previous studies reported the existence of both D1- and D2-like receptors in the cortical collecting duct (CCD). However, especially with regard to natriuresis, it remains controversial. In the present study, rabbit CCD was perfused to characterize the receptor subtypes responsible for the tubular actions. Basolateral dopamine (DA) induced a dose-dependent depolarization of transepithelial voltage. Basolateral domperidone, a D2-like receptor antagonist, abolished depolarization, whereas SKF… CONTINUE READING

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