Functional characterization of a single nucleotide polymorphism in the 5' UTR region of the bovine toll-like receptor 4 gene.

Abstract

Toll-like receptor 4 (TLR4) is the key receptor for the LPS component of Gram-negative bacteria. We have identified a SNP within the 5' UTR region of the bovine TLR4 gene at position 226 (c.-226C>G) relative to start codon, which was found to be associated with health related traits in the Canadian Holstein population. TLR4 gene expression was measured over… (More)

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@article{Sharma2008FunctionalCO, title={Functional characterization of a single nucleotide polymorphism in the 5' UTR region of the bovine toll-like receptor 4 gene.}, author={Bhawani Singh Sharma and Jim Mount and Niel A. Karrow}, journal={Developments in biologicals}, year={2008}, volume={132}, pages={331-6} }