Functional characterization of a promoter polymorphism in APE1/Ref-1 that contributes to reduced lung cancer susceptibility.

@article{Lu2009FunctionalCO,
  title={Functional characterization of a promoter polymorphism in APE1/Ref-1 that contributes to reduced lung cancer susceptibility.},
  author={Juan J. Lu and Shuyu Zhang and Dan Chen and Huibo Wang and Wenting Wu and Xiaotian Wang and Yunping Lei and Jiu-cun Wang and Ji Qian and Weiwei Fan and Zhibin Hu and Li Jin and Hongbing Shen and Wei Huang and Qingyi Wei and Daru Lu},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2009},
  volume={23 10},
  pages={3459-69}
}
Apurinic/apyrimidinic endonuclease 1/redox effector factor-1 (APE1/Ref-1) is a ubiquitous multifunctional protein that possesses both DNA-repair and redox regulatory activities. Although it was originally identified as a DNA-repair enzyme, accumulating evidence supports a role of APE1/Ref-1 in tumor development. To investigate association between APE1/Ref-1 polymorphisms and lung cancer risk in Chinese populations, we first genotyped three variants of APE1/Ref-1 and found a -141 T-to-G variant… CONTINUE READING

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