Functional characterization of a novel Ku70/80 pause site at the H19/Igf2 imprinting control region.

@article{Katz2005FunctionalCO,
  title={Functional characterization of a novel Ku70/80 pause site at the H19/Igf2 imprinting control region.},
  author={David J. Katz and Michael A. Beer and John M. Levorse and Shirley M. Tilghman},
  journal={Molecular and cellular biology},
  year={2005},
  volume={25 10},
  pages={3855-63}
}
The imprinted expression of the H19 and Igf2 genes in the mouse is controlled by an imprinting control center (ICR) whose activity is regulated by parent-of-origin differences in methylation. The only protein that has been implicated in ICR function is the zinc-finger protein CTCF, which binds at multiple sites within the maternally inherited ICR and is required to form a chromatin boundary that inhibits Igf2 expression. To identify other proteins that play a role in imprinting, we employed… CONTINUE READING

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