Functional characterization of a Trypanosoma brucei TATA-binding protein-related factor points to a universal regulator of transcription in trypanosomes.

@article{Ruan2004FunctionalCO,
  title={Functional characterization of a Trypanosoma brucei TATA-binding protein-related factor points to a universal regulator of transcription in trypanosomes.},
  author={Jia-peng Ruan and George K. Arhin and Elisabetta Ullu and Christian Tschudi},
  journal={Molecular and cellular biology},
  year={2004},
  volume={24 21},
  pages={9610-8}
}
Transcriptional mechanisms remain poorly understood in trypanosomatid protozoa. In particular, there is no knowledge about the function of basal transcription factors, and there is an apparent rarity of promoters for protein-coding genes transcribed by RNA polymerase (Pol) II. Here we describe a Trypanosoma brucei factor related to the TATA-binding protein (TBP). Although this TBP-related factor (TBP-related factor 4 [TRF4]) has about 31% identity to the TBP core domain, several key residues… CONTINUE READING

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