Functional characterization of Rho GTPases in Aspergillus niger uncovers conserved and diverged roles of Rho proteins within filamentous fungi.

@article{Kwon2011FunctionalCO,
  title={Functional characterization of Rho GTPases in Aspergillus niger uncovers conserved and diverged roles of Rho proteins within filamentous fungi.},
  author={Min Jin Kwon and Mark Arentshorst and Eelke D Roos and Cees A. M. J. J. van den Hondel and Vera Meyer and Arthur F. J. Ram},
  journal={Molecular microbiology},
  year={2011},
  volume={79 5},
  pages={1151-67}
}
Rho GTPases are signalling molecules regulating morphology and multiple cellular functions including metabolism and vesicular trafficking. To understand the connection between polarized growth and secretion in the industrial model organism Aspergillus niger, we investigated the function of all Rho family members in this organism. We identified six Rho GTPases in its genome and used loss-of-function studies to dissect their functions. While RhoA is crucial for polarity establishment and… CONTINUE READING