Functional characterization of PhoPR two component system and its implication in regulating phosphate homeostasis in Bacillus anthracis.

@article{Aggarwal2017FunctionalCO,
  title={Functional characterization of PhoPR two component system and its implication in regulating phosphate homeostasis in Bacillus anthracis.},
  author={Somya Aggarwal and Vikas Kumar Somani and Vatika Gupta and Jaspreet Kaur and Damini Singh and Abhinav Grover and Rakesh Bhatnagar},
  journal={Biochimica et biophysica acta. General subjects},
  year={2017},
  volume={1861 1 Pt A},
  pages={
          2956-2970
        }
}
BACKGROUND Recent report on importance of phosphate starvation (PS) in Bacillus anthracis (BA) pathogenesis warrants further investigation of the underlying regulatory mechanism. Potential role of PhoPR two component system (TCS) in phosphate homeostasis and virulence of several pathogens necessitates the study of annotated PhoPR in BA. METHODS Expression of phoP and phoR was analyzed using qRT-PCR. PhoPR was characterized biochemically. DNA-protein interaction was analyzed by EMSA. Docking… CONTINUE READING
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