Functional characterization of HIV-1 Nef mutants in the context of viral infection.

@article{Fackler2006FunctionalCO,
  title={Functional characterization of HIV-1 Nef mutants in the context of viral infection.},
  author={O. Fackler and A. Moris and Nadine Tibroni and Simone I. Giese and B. Glass and O. Schwartz and H. Kr{\"a}usslich},
  journal={Virology},
  year={2006},
  volume={351 2},
  pages={
          322-39
        }
}
  • O. Fackler, A. Moris, +4 authors H. Kräusslich
  • Published 2006
  • Biology, Medicine
  • Virology
  • Nef is an important pathogenesis factor of HIV-1 with a multitude of effector functions. We have designed a broad panel of isogenic viruses encoding defined mutants of HIV-1(SF2) Nef and analyzed their biological activity in the context of productive HIV-1 infection. Analysis of subcellular localization, virion incorporation, downregulation of cell surface CD4 and MHC-I, enhancement of virion infectivity and facilitation of HIV replication in primary human T lymphocytes mostly confirmed the… CONTINUE READING
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