Functional characterization of HIV-1 Nef mutants in the context of viral infection.

@article{Fackler2006FunctionalCO,
  title={Functional characterization of HIV-1 Nef mutants in the context of viral infection.},
  author={Oliver T. Fackler and Arnaud Moris and Nadine Tibroni and Simone I Giese and B{\"a}rbel Glass and Olivier Schwartz and Hans-Georg Kr{\"a}usslich},
  journal={Virology},
  year={2006},
  volume={351 2},
  pages={
          322-39
        }
}
Nef is an important pathogenesis factor of HIV-1 with a multitude of effector functions. We have designed a broad panel of isogenic viruses encoding defined mutants of HIV-1(SF2) Nef and analyzed their biological activity in the context of productive HIV-1 infection. Analysis of subcellular localization, virion incorporation, downregulation of cell surface CD4 and MHC-I, enhancement of virion infectivity and facilitation of HIV replication in primary human T lymphocytes mostly confirmed the… CONTINUE READING

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