Functional characterization of EBV-encoded nuclear antigen 1-specific CD4+ helper and regulatory T cells elicited by in vitro peptide stimulation.

@article{Voo2005FunctionalCO,
  title={Functional characterization of EBV-encoded nuclear antigen 1-specific CD4+ helper and regulatory T cells elicited by in vitro peptide stimulation.},
  author={Kui Shin Voo and Guangyong Peng and Zhong Ning Guo and Tihui Fu and Yanchun Li and Lori Frappier and Rong-fu Wang},
  journal={Cancer research},
  year={2005},
  volume={65 4},
  pages={
          1577-86
        }
}
CD4(+) helper and regulatory T (Treg) cells play important but opposing roles in regulating host immune responses against cancer and other diseases. However, very little is known about the antigen specificity of CD4(+) Treg cells. Here we describe the generation of a panel of EBV-encoded nuclear antigen 1 (EBNA1)-specific CD4(+) T-cell lines and clones that recognize naturally processed EBNA1-P(607-619) and -P(561-573) peptides in the context of HLA-DQ2 and HLA-DR11, -DR12, and -DR13 molecules… CONTINUE READING

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