Functional characterization and developmental regulation of mouse telomerase RNA

@article{Blasco1995FunctionalCA,
  title={Functional characterization and developmental regulation of mouse telomerase RNA},
  author={M. Blasco and W. Funk and B. Villeponteau and C. Greider},
  journal={Science},
  year={1995},
  volume={269},
  pages={1267 - 1270}
}
Telomerase synthesizes telomeric DNA repeats onto chromosome ends de novo. The mouse telomerase RNA component was cloned and contained only 65 percent sequence identity with the human telomerase RNA. Alteration of the template region in vivo generated altered telomerase products. The shorter template regions of the mouse and other rodent telomerase RNAs could account for the shorter distribution of products (processivity) generated by the mouse enzyme relative to the human telomerase. Amounts… Expand
366 Citations
The RNA component of human telomerase
Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA
The implications of telomerase biochemistry for human disease.
  • G. Morin
  • Biology, Medicine
  • European journal of cancer
  • 1997
Mouse models for the study of telomerase.
Expression of mouse telomerase catalytic subunit in embryos and adult tissues.
Functionally interacting telomerase RNAs in the yeast telomerase complex.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 15 REFERENCES
Identification of a nonprocessive telomerase activity from mouse cells.
Developmental and tissue-specific regulation of mouse telomerase and telomere length.
  • K. Prowse, C. Greider
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1995
Hypervariable ultra-long telomeres in mice
...
1
2
...